High vaccine effectiveness against severe COVID-19 in the elderly in Finland before and after the emergence of OmicronArticle Published on 2022-11-052022-11-16 Journal: BMC Infectious Diseases [Category] SARS, 변종, [키워드] 95% CI Admission caused Cohort cohort analysis COVID-19 COVID-19 hospitalization COVID-19 vaccines dose doses Effectiveness elderly Elderly cohort evaluated Follow-up hazard ratio Heterologous homologous Hospitalization ICU ICU treatment Immunity individuals intensive care omicron outcome protection reduced remained restored SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 Omicron variant severe COVID-19 vaccination Vaccine waned Waning vaccine effectiveness. [DOI] 10.1186/s12879-022-07814-4 PMC 바로가기
Longitudinal cellular and humoral immune responses after triple BNT162b2 and fourth full-dose mRNA-1273 vaccination in haemodialysis patientsArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] ACE2 binding addition administration analysed anti-RBD B.1 binding BNT162b2 boost immunity cellular Control controls COVID-19 COVID-19 vaccination Decline declining Delta detectable dialysis dose doses group Haemodialysis Haemodialysis patient humoral humoral immune response Humoral immunity IgG IgG response immune immune evasion immune protection immunoassays Immunocompromised individual individuals information interferon γ knowledge longitudinal longitudinal response maintain mixed mRNA vaccination mRNA mRNA vaccination mRNA-1273 mucosal omicron Omicron variant of concern Patient patients Prevent protective immunity protective immunity. RBD reached regimen remained respond poorly restored SARS-CoV-2 vaccination SARS-CoV-2 variant second vaccination severe COVID-19 significantly increased spike subsequent Support T-cell Response tested the receptor-binding domain vaccination Vaccine variant variants of concern [DOI] 10.3389/fimmu.2022.1004045 PMC 바로가기
SARS-CoV-2-specific antibodies and neutralization capacity in breast milk following infection vs vaccinationArticle Published on 2022-09-012022-11-15 Journal: Ultrasound in obstetrics & gynecology : the offici [Category] SARS, 진단, [키워드] acute respiratory syndrome anti-SARS-CoV-2 antibody antibody binding booster dose both groups breast milk changes in children collected convenience sampling coronavirus coronavirus disease COVID-19 COVID-19 vaccine evaluate first dose Gynecology highlight IgA IgA level immunoglobulin A individuals Infection median natural infection neutralization capacity Neutralizing neutralizing antibody peaking Prospective Study rapid increase receive recruited restored SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific antibody secretion Society stimulated study groups the median the vaccine Ultrasound undetectable vaccination vaccination. Vaccine women [DOI] 10.1002/uog.24965 PMC 바로가기
BRET-Based Self-Cleaving Biosensors for SARS-CoV-2 3CLpro Inhibitor DiscoveryArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료제, [키워드] 293T cells 3C-like protease 3CLpro Activation activity anti-SARS-CoV-2 activities Antiviral biosensor BRET BSL-2 BSL-2 laboratory BSL-3 C-terminus can be used Cell cellular cleavage clinical trial coronavirus diseases COVID-19 COVID-19 treatments decrease drug target embryonic kidney energy transfer evaluate evaluated fluorescent inhibitor inhibitors level 3 linker N-terminus overexpression polyproteins protease Protein released Renilla luciferase reported reproducibility restored resulting SARS-CoV-2 self-cleavage self-cleaving biosensor. sequence small molecule inhibitor treat virus [DOI] 10.1128/spectrum.02559-21 PMC 바로가기
Association of Frailty, Age, and Biological Sex With Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccine-Induced Immunity in Older Adults중증 급성 호흡기 증후군 코로나바이러스 2 메신저 RNA 백신 유도 면역과 노쇠, 연령 및 생물학적 성별의 연관성Article Published on 2022-08-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 치료법, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adults age aging antibody Antibody binding Antibody Response Antibody responses Antibody titer binding Biological Breakthrough infection breakthrough infections caused characterized collected coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Coverage declined Delta domain dose eliminated female females frailty functional functional antibody response functional antibody responses greater Intersection male Male sex males messenger mRNA vaccination neutralization nucleocapsid old age Older older adult omicron plasma samples Promoting receipt reduced respiratory response restored risk factor Risk factors RNA SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens second dose severe acute respiratory syndrome Coronavirus severe coronavirus disease Sex sex differences. significantly Spike protein the vaccine Vaccine vaccine dose variant variants of concern virus virus VoC VOCs vulnerable population were measured [DOI] 10.1093/cid/ciac397 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathwaySARS-CoV-2 Omicron은 세포 진입 경로가 변경된 면역 탈출 변종입니다.Article Published on 2022-08-012022-09-11 Journal: Nature Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] Amino acid antigenicity B.1.1.529 BNT162b2 booster vaccination Cell cell entry Cell fusion ChAdOx1 changes in cornerstone COVID-19 described determined by Effectiveness endosomal entry endosomal entry pathway Immune escape Impaired in vitro increasingly individual induce mapped mRNA mRNA-1273 Mutation neutralization omicron Omicron variant Omicron variants pathogenicity pathway phenotype public health Receptor-binding domain reduction in Region replicative restored S2 domain SARS-CoV-2 sera Spike protein Spread Syncytia the receptor-binding domain the spike protein These data TMPRSS2 transmissible variant underlie Vaccine variant VoC VOCs was determined [DOI] 10.1038/s41564-022-01143-7 PMC 바로가기 [Article Type] Article
Detecting COVID-19 patients via MLES-Net deep learning models from X-Ray imagesX-Ray 이미지에서 MLES-Net 딥 러닝 모델을 통해 COVID-19 환자 감지Article Published on 2022-07-302022-09-11 Journal: BMC Medical Imaging [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy Attention automatically average calculation categories category caused Characteristics chest X-ray Chest X-ray images Classifier classifiers Convolutional neural network convolutional neural network (CNN) Corona Coronavirus infection correlation COVID-19 COVID-19 patient cumulative death deep deep learning diagnose Diagnosis Dot product Efficiency enhanced experimental results Factor feature Final generate IMPROVE information initial Local Mask MLES-Net. multiple groups network network model normalized Novel coronavirus Novel coronavirus infection parameter parameters Pneumonia Prevent problems restored scaled sensation similarity Spread Variability virus Virus Disease was obtained [DOI] 10.1186/s12880-022-00861-y PMC 바로가기 [Article Type] Article
Disruptions, restorations and adaptations to health and nutrition service delivery in multiple states across India over the course of the COVID-19 pandemic in 2020: An observational studyObservational Study Published on 2022-07-272022-10-04 Journal: PLoS ONE [Category] 임상, [키워드] adaptation analyzed Anganwadi antagonistic change children conducted counseling Course COVID-19 COVID-19 pandemic Critical events Evidence fixed food growth Guidance Health health system highlight immunization Impact India lockdown mitigate modeling MOST mother outcomes pandemic Personal protective equipment populations pregnant women provided Rapid reached reported restored service Seven Variability [DOI] 10.1371/journal.pone.0269674 PMC 바로가기 [Article Type] Observational Study
Immunogenicity evaluation after BNT162b2 booster vaccination in healthcare workers의료 종사자의 BNT162b2 추가 접종 후 면역원성 평가Article Published on 2022-07-262022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] BNT162b2 booster booster vaccination Contact contact with exposure to first vaccination followed by HCW healthcare worker Healthcare workers humoral Humoral response IgA IgA antibodies IgA antibody IgA level IgA levels IgG IgG level IgG levels immune response Immunity immunogenicity implementation increase in Infection Measures new virus pandemic patients Registered restored SARS-COV-2 infection significantly statistically subject the antibody vaccination Vaccine variants virus [DOI] 10.1038/s41598-022-16759-2 PMC 바로가기 [Article Type] Article
Longitudinal Serum Proteome Characterization of COVID-19 Patients With Different Severities Revealed Potential Therapeutic Strategies다양한 중증도를 가진 COVID-19 환자의 세로 혈청 프로테옴 특성이 잠재적인 치료 전략을 드러냄Article Published on 2022-07-262022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation alteration Analysis Asymptomatic asymptomatic patient asymptomatic patients caused characterization cholesterol cholesterol metabolism Cluster cluster analysis coagulation cascade collected complement Complement activation control group control groups COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients disease Disease progression dysregulation effective expand global healthcare heterogeneity Hierarchical hierarchical cluster analysis immune response individuals involved longitudinal metabolism Mild moderate Moderate COVID-19 moderate COVID-19 patients molecular Non-COVID-19 not recovered Pathogenesis pathophysiological Patient patients performed PLGLB1 Potential potential therapeutic target potential therapeutic targets progression Protein Proteins proteomic proteomics restored Revealed SARS-CoV-2 serum serum biomarker serum biomarkers Serum level serum sample serum samples severity Severity. Strategy symptomatic Treatment understanding [DOI] 10.3389/fimmu.2022.893943 PMC 바로가기 [Article Type] Article